Ngawo-1990, ochwepheshe bezokwelapha baseSwitzerland bathola ukuthi ama-platelet angakwazi ukukhiqiza inani elikhulu lezici zokukhula ezindaweni eziphezulu, ezingalungisa ngokushesha nangempumelelo izilonda zezicubu.Kamuva, i-PRP yasetshenziswa ekuhlinzeni okuhlukahlukene kwangaphakathi nangaphandle, ukuhlinzwa kwepulasitiki, ukufakelwa kwesikhumba, njll.
Ngaphambilini sethule ukusetshenziswa kwe-PRP (i-Platelets Rich Plasma) ekufakweni kwezinwele ukusiza ukubuyisela isilonda nokukhula kwezinwele;Yiqiniso, ukuhlolwa okulandelayo okumele uzame ukwandisa ukumbozwa kwezinwele eziyinhloko ngokujova i-PRP.Ake sibone ukuthi yimiphi imiphumela ezotholakala ngokujova i-autologous platelet enothisa i-plasma kanye nezici ezihlukahlukene zokukhula ezigulini zesilisa ezine-alopecia, okuphinde kube yindlela yokwelapha esingalindela ukukusebenzisa ukulwa nokulahlekelwa izinwele.
Ngaphambi nangesikhathi senqubo yonke yokufakelwa izinwele, iziguli eziphathwa nge-PRP kanye nalezo ezingajovwe nge-PRP zingenza izinwele zikhule ngokushesha.Ngasikhathi sinye, umbhali uphinde wahlongoza ucwaningo lokuqinisekisa ukuthi i-plasma ecebile ye-platelet inomphumela ofanayo ekuthuthukiseni izinwele ezinhle.Hlobo luni lwesilonda okufanele lusetshenziswe futhi singakanani isici sokukhula okufanele sijovwe ngokuqondile ukuze siphumelele?Ingabe i-PRP ingakwazi ukubuyisela ukuncipha kancane kancane kwezinwele ku-alopecia ye-androgenic, noma ingabe ingakhuthaza ngempumelelo ukukhula kwezinwele ukuze kuthuthukiswe i-alopecia ye-androgenic noma ezinye izifo zokulahlekelwa izinwele?
Kulolu cwaningo oluncane lwezinyanga eziyisishiyagalombili, i-PRP yajova esikhumbeni se-androgenic alopecia ne-alopecia.Uma kuqhathaniswa neqembu elilawulayo, lingakwazi ngempela ukuhlehlisa ukuncipha kancane kancane kwezinwele;Ngaphezu kwalokho, lapho ujova ezigulini ezinempandla eyindilinga, ukukhula kwezinwele ezintsha kungabonakala inyanga eyodwa kamuva, futhi umphumela ungahlala isikhathi esingaphezu kwezinyanga eziyisishiyagalombili.
Isingeniso
Ku-2004, lapho omunye wabacwaningi ephatha isilonda sehhashi nge-PRP, isilonda saphola phakathi nenyanga eyodwa futhi izinwele zakhula, bese i-PRP isetshenziselwa ukuhlinzwa kokufakelwa kwezinwele;Abacwaningi baphinde bazama ukujova i-PRP ekhanda leziguli ngaphambi kokufakelwa kwezinwele, futhi bathola ukuthi izinwele zeziguli zibonakala ziba mkhulu (1).Abacwaningi bakholelwa ukuthi i-revascularization kanye nomthelela wokuqukethwe okuphezulu kwesici sokukhula kungase kukhuthaze ukukhula kwamangqamuzana ezinwele zezinwele ekhanda lendawo engasebenzi.Igazi licutshungulwa ngokukhethekile.Ama-platelet ahlukaniswa kwamanye amaprotheni e-plasma futhi aqukethe ukugxila okuphezulu kwamaplatelet.Ukuze ufinyelele izinga lomphumela wokwelapha, kusukela ku-microliter engu-1 (0.000001 litre) equkethe ama-platelet angu-150000-450000 kuya ku-1 microliter (0.000001 litre) equkethe i-1000000 platelet (2).
I-Platelet α inezinhlobo eziyisikhombisa zezinto zokukhula kuma-granules, okuhlanganisa i-epithelial growth factor, i-fibroblast growth factor, i-thrombogen growth factor kanye ne-transforming growth factor α, Interleukin-1, kanye ne-vascular endothelial growth factor (VEGF).Ngaphezu kwalokho, i-peptide elwa namagciwane, i-catecholamines, i-serotonin, i-Osteonectin, i-von Willebrand factor, i-proaccelenn nezinye izinto zengezwa.Izinhlayiya eziwugqinsi zinezinhlobo ezingaphezu kwe-100 zezinto zokukhula, ezingasebenza ezilonda.Ngaphandle kwezici zokukhula, i-platelet sparse plasma (PPP) eyodwa iqukethe ama-molecule amathathu e-cell adhesion (CAM), i-Fibrin, i-fibronectin, ne-vitronectin, iphrotheni esebenzayo ebeka isakhiwo esiyinhloko namagatsha ukulawula ukukhula kwamangqamuzana, ukunamathela, ukwanda, umehluko kanye nokuvuselelwa.
Takakura, et al.yathi i-PDCF (i-platelet derived growth factor) isignali ihlobene nokusebenzisana kwezinhlayiya zezinwele ze-epidermal kanye namaseli e-dermal stromal, futhi iyadingeka ukuze kwakhiwe imigudu yezinwele (3).Ngo-2001, u-Yano et al.uveze ukuthi i-VFLGF ilawula ikakhulukazi umjikelezo wokukhula kwezinwele, ihlinzeka ngobufakazi obuqondile bokuthi ukwanda kwe-hair follicle vascular reconstruction kungakhuthaza ukukhula kwezinwele futhi kwandise i-follicle yezinwele nosayizi wezinwele (4).
PS: I-Platelet derived growth factor, PDCF.Isici sokuqala sokukhula esigunyazwe i-US FDA ukwelapha ukulimala kwesikhumba okungapheli kuyisici sokuqala sokukhula esikhishwe ngokukhuthazwa ngemva kokulimala kwesikhumba.
PS: I-Vascular endothelial growth factor, i-VEGF.Ingenye yezinto ezibaluleke kakhulu zokulawula ezilawula ukwanda kwamangqamuzana e-endothelial, i-angiogenesis, i-vasculogenesis kanye ne-vascular permeability.
Uma sikholelwa ukuthi lapho izinhlayiya zezinwele sezishwabene kangangokuthi asikwazi ukubona ukukhula kwezinwele ngeso lenyama, lisekhona ithuba lokuba izimpande zoboya zikhule izinwele (5).Ngaphezu kwalokho, uma izinwele zezinwele zezinwele ezinhle zifana nalezo zezinwele ezimahhadla, kukhona ama-stem cells anele ku-epidermis kanye neqhubu (6), kungenzeka ukwenza izinwele zibe mncane futhi zibe mkhulu empandleni wesilisa.
(Qaphela: Lesi sihloko siphrintwe kabusha. Inhloso ye-athikili ukudlulisa ulwazi olufanele kabanzi kabanzi. Inkampani ayizibophezeli ngokunemba, ubuqiniso, ukuba semthethweni kokuqukethwe kwayo, kanye nokubonga ukuqonda.)
Isikhathi sokuthumela: Mar-15-2023